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Published on:April 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(2s):S68-S75
Pharmaceutical Research | doi:10.5530/ijper.50.2.20

Solubility Enhancement of Satranidazole Using Self Emulsified Drug Delivery Systems


Authors and affiliation (s):

Nitin Pandurang Gurav1*, Panchaxari Mallappa Dandagi1, Anand Panchaxari Gadad1, Vinayak Shivamurthi Masthiholimath2

1Department of Pharmaceutics, KLES College of Pharmacy Belagavi Karnataka-590010, INDIA.

2Department of Quality Assurance, KLES College of Pharmacy Belagavi Karnataka-590010, INDIA.

Abstract:

Background: Satranidazole is an antiprotozoal and antibacterial drug which falls under class II drug as per biopharmaceutical classification systems having poor aqueous solubility. Aim: Therefore, present study was aimed at solubility enhancement of Satranidazole using self emulsified drug delivery system (SEDDS). Methods: SEDDS was prepared using Oleic acid as oil, Tween 20 and PEG400 as Surfactant and Co-surfactant respectively. For preparation of stable SEDDS, micro emulsion region was identified by constructing pseudo ternary phase diagram containing different proportion of surfactant: co-surfactant (1:1, 2:1 and 3:1), oil and water. Physico-Chemical Evaluation: Total nine SEDDS formulations were prepared (F-1 to F-9) and evaluated for self emulsification time & dispersibility, droplet size analysis, stability studies, turbidimetry, zeta potential, drug content and in vitro drug release. Results: Among all the formulations, three formulations (F-1, F-4 & F-7) showed a drug release of greater than 70% in 45 minutes whereas marketed preparation showed more than 70% of drug release in 90 minutes. Based on results of self emulsification time & dispersibility, droplet size analysis, drug content and in vitro drug release, F-7 formulation was selected as an optimized formulation which showed a maximum drug release of 94.89% in 45 minutes. Conclusion: Hence SEDDS formulations can be a potential alternative to traditional oral drug delivery systems of Satranidazole to improve its solubility.

Key words: Satranidazole, Surfactants, Lipid vehicles, Pseudo ternary phase diagrams, SEDDS.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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