Home | Articles
Published on:31 Mar 2013
Indian Journal of Pharmaceutical Education and Research, 2013; 47(1):27-33
Original Article | doi:

Enhanced Iontophoretic Delivery of Sumatriptan Succinate from Thermosensitive Gel using Chemical Enhancers


Authors and affiliation (s):

Swapnil T. Deshpande1*, Swaroop R. Lahoti1, Dinesh L.Dhamecha1, Vivek B. Rajendra1, Mohd. Hassan
G.Dehghan1, Prashant K. Puranik2
1Department of Pharmaceutics, Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India.
2Government College of Pharmacy, Aurangabad, Maharashtra, India.
 

Abstract:

The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Sumatriptan succinate (SS) by iontophoresis. For better bioavailability, better patient compliance, and enhanced delivery of SS, an iontophoretic drug delivery system of a thermo sensitive SS gel was formulated using Lutrol F-127. The study was conducted using silver–silver chloride electrodes across hairless pig skin. The effects of pH, pulsed current, polymer concentration, drug concentration, synergistic effect of penetration enhancers on the SS permeation were investigated. Iontophoretic transport of SS was found to increase with increase in the pH of the medium. Viscosity measurements and flux calculations indicated the suitability of the Lutrol gel for transdermal iontophoretic delivery of SS. Anodal pulsed iontophoresis significantly increases the skin permeation of SS at pulsed ratio 1:1 in combination with PEG-400 as penetration enhancers compared with the passive controls.

Keywords: Iontophoresis, Sumatriptan Succinate, Thermosensitive gel.

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the Latest Release of Journal Citation Reports (source: Web of Science Data).

 

Impact Factor® as reported in the 2023 Journal Citation Reports® (Clarivate Analytics, 2023): 0.8

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs