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Published on:August 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(3):376-384
Original Article | doi:10.5530/ijper.50.3.9

Effects of Nigella sativa (Kalonji) and Honey on Lipid Profile of Hyper lipidemic Smokers


Authors and affiliation (s):

Inayatullah Bhatti1, Saira Inayat2, Bushra Uzair3, Farid Menaa4, Sattar Bakhsh1, Haroon Khan1, Falak Naz1, Barkat Ali Khan1*

1Faculty of Pharmacy, Gomal University, Dera Ismail Khan 29500, Khyber Pakhtunkhwa, PAKISTAN.

2Department of Biological Sciences, Gomal University, Khan 29500, Khyber Pakhtunkhwa, PAKISTAN.

3Department of Bioinformatics & Biotechnology, International Islamic University, Islamabad, PAKISTAN.

4Department of Pharmaceutical Sciences and Nanomedicine, Fluorotronics Inc., San Diego, CA, USA.

Abstract:

Background: Hyper lipidemia refers to the excess of lipids in the blood of patients. The present study was carried out to investigate the effect of Nigella sativa (kalonji) and honey as compared with Atorvastatin on the lipid profile of hyper lipidemia patients with habit of smoking. Methodology: Purposes, 60 patients (3 groups of 20) of 35-65 years were selected. These patients were treated with 1 g of Nigella sativa (kalonji) seed, one tablespoon of honey, and Atorvastatin 10 mg daily in the morning at fasting for a period of 30 days. Results: The results obtained showed that Nigella sativa (kalonji), honey as well as Atorvastatin lowered significantly the levels of total cholesterol (TC), low density lipoproteins (LDL) and triglycerides (TGs) after 30 days of treatment. On the other hand, all the treatments increased HDL levels significantly after 30 days treatments were non-significant on TC and LDL levels of smokers. But after 30 days of treatment, Atorvastatin was significantly more effective than honey and Nigella sativa (kalonji). Honey reduced TGs level of smokers significantly over Nigella sativa (kalonji) and Atorvastatin. Conclusion: It can be concluded that both Nigella sativa (kalonji) and honey were as effective as Atorvastatin or more effective in some cases in reducing TC, LDL and TGs of hyper lipidemic smokers significantly while HDL levels were increased significantly.

Key words: Alternative and Complementary Medicine, Atorvastatin, Honey, Hyper lipidemia, Smoking, Kalonji, Preventive Medicine, Smoking.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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