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Published on:August 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(3):424-434
Original Article | doi:10.5530/ijper.50.3.16

Synthesis, Characterization, Molecular Docking Studies and Antimicrobial Evaluation of N-Benzimidazol-1-Yl-Methyl-Benzamide Derivatives


Authors and affiliation (s):

Ritchu Sethi1, Sandeep Arora1, Deepika Saini2 and Sandeep Jain2*

1Chitkara College of Pharmacy, Chitkara University, Rajpura, Distt. Patiala-140401, INDIA.

2Department of Pharmaceutical Sciences Guru Jambheshwar University, Hissar-125001, INDIA.

Abstract:

N-benzimidazol-1-yl-methyl-benzamide derivatives (3a-3x) were synthesized by Mannich reaction and evaluated for in vitro antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Candida albicans and Aspergillus niger. The structures of novel target compounds were elucidated by spectral and analytical techniques. Among the synthesized derivatives, 3o N-[2-(2-chloro-phenyl)- benzimidazol-1-ylmethyl]-benzamide, 3q N-[2-(4-chloro-phenyl)-benzimidazol-1ylmethyl]- benzamide and 3r N-[2-(2-bromo-phenyl)-benzimidazol-1-ylmethyl]-benzamide were found to be most effective antimicrobial compounds. Clotrimazole and ciprofloxacin were used as reference antimicrobial agents. Further, in silico studies were carried out to define the interaction of the title compounds with microbial protein.

Key words: Mannich bases, Benzimidazole, Antibacterial activity, Antifungal activity, Docking study.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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