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Published on:August 2016
10.5530/ijper.50.3.20, 2016; 50(3):458-464
Original Article | doi:10.5530/ijper.50.3.20

A Diterpenoid Taxoquinone from Metasequoia Glyptostroboides with Pharmacological Potential.


Authors and affiliation (s):

Vivek Kumar Bajpai1, Irfan Ahmad Rather1, Sun Chul Kang2*, Yong-Ha Park1*

1Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbook 712-749, KOREA.

2Department of Biotechnology, College of Engineering, Daegu University, Gyeongsan, Gyeongbook 712-714, KOREA.

Abstract:

Background: The ubiquitin-proteasome pathway plays an important role in selective protein degradation and regulates multiple cellular processes, including cell cycle progression, proliferation and apoptosis. Cancer cells are more sensitive to the pro-apoptotic effects of proteasome inhibition than normal cells, hence, proteasome inhibitors can be used as novel anticancer drugs. Further, influenzacommonly known as “flu” is a contagious respiratory disease caused by sub-type of influenza A virus H1N1 which has resulted in enormous medical attention world-wide. Natural products are well known for their pharmacological potential in anticancer and antiviral therapies. Methods: In this study, an abietane-type diterpenoid, taxoquinone, isolated from Metasequoia glyptostroboides, was assessed for the first time for its therapeutic efficacy as a potential inhibitor of influenza A (H1N1) virus and 20S proteasomeusing cytopathic reduction assay and proteasome inhibition assay, respectively. Results: The taxoquinonedisplayed its anticancer effect in terms its ability to inhibit 20S human proteasome with IC50 value of 8.2 ± 2.4 μg/μL. Moreover, taxoquinone (500 μg/mL) displayed significant antiviral effect against H1N1 influenza virus in cytopathic reduction assay on MDCK cell line. Conclusion: These finding confirm pharmaceutical potential of taxoquinone as a novel therapeutic agent.

Key words: Anticancer, Antiviral, Taxoquinone, Diterpenoid, Metasequoia glyptostroboides.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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