Home | Articles
Published on:August 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(3):482-488
Original Article | doi:10.5530/ijper.50.3.23

Application of TLC-Densitometry for Analysis of Estradiol Hemihydrate in Dosage Forms.


Authors and affiliation (s):

Dobrina Doncheva Tsvetkova1, Danka Petrova Obreshkova1,2, Stefka Achkova Ivanova1,2, Bozhidarka Hadjieva3, Peter Yordanov Atanasov4

1Medical University-Sofia, Faculty of Pharmacy, Department of Pharmaceutical Chemistry,

2Medical University-Plovdiv, Faculty of Pharmacy, Department of Pharmacognosy and Pharmaceutical Chemistry, 15A Vasil Aprilov Str., Plovdiv 4002, BULGARIA.

3Medical University-Plovdiv, Medical College, 15A Vasil Aprilov Str., Plovdiv 4002, BULGARIA.

4Clinic of Internal Diseases UMHATEM ”N. I. Pirogov”-SOFIA, BULGARIA.

Abstract:

The aim of current study was the application of validated TLC-densitometric method for identification and determination of Estradiol hemihydrate in dosage forms. The applied TLC conditions were: Silicagel G60F254 glass plates; mobile phase: chloroform : acetone = 90 : 10 v/v, migration distance of mobile phase: 120 mm, UV-detection at  = 254 nm. All of the experimental results for the content of Estradiol hemihydrate correspond to the respective confidence interval: Estrofem table: 1.78 mg ÷ 2.12 mg; Femoston F1 table: 1.88 mg ÷ 2.2 mg; Femoston F2 table: 1.99 mg ÷ 2.19 mg; Trisequens T1 table: 1.78 mg ÷ 2.18 mg; Trisequens T2 table: 1.92 mg ÷ 2.12 mg; Trisequens T3 table: 0.97 mg ÷ 1.17 mg. The proposed validated TLC-densitometric method is appropriate for quality control of Estradiol hemihydrate in commercially available tablets.

Key words: Estradiol hemihydrate, TLC, Densitometry, Tablets, analysis, Determination.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
13 + 3 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
7 + 4 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs