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Published on:August 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(3):482-488
Original Article | doi:10.5530/ijper.50.3.23

Application of TLC-Densitometry for Analysis of Estradiol Hemihydrate in Dosage Forms.


Authors and affiliation (s):

Dobrina Doncheva Tsvetkova1, Danka Petrova Obreshkova1,2, Stefka Achkova Ivanova1,2, Bozhidarka Hadjieva3, Peter Yordanov Atanasov4

1Medical University-Sofia, Faculty of Pharmacy, Department of Pharmaceutical Chemistry,

2Medical University-Plovdiv, Faculty of Pharmacy, Department of Pharmacognosy and Pharmaceutical Chemistry, 15A Vasil Aprilov Str., Plovdiv 4002, BULGARIA.

3Medical University-Plovdiv, Medical College, 15A Vasil Aprilov Str., Plovdiv 4002, BULGARIA.

4Clinic of Internal Diseases UMHATEM ”N. I. Pirogov”-SOFIA, BULGARIA.

Abstract:

The aim of current study was the application of validated TLC-densitometric method for identification and determination of Estradiol hemihydrate in dosage forms. The applied TLC conditions were: Silicagel G60F254 glass plates; mobile phase: chloroform : acetone = 90 : 10 v/v, migration distance of mobile phase: 120 mm, UV-detection at  = 254 nm. All of the experimental results for the content of Estradiol hemihydrate correspond to the respective confidence interval: Estrofem table: 1.78 mg ÷ 2.12 mg; Femoston F1 table: 1.88 mg ÷ 2.2 mg; Femoston F2 table: 1.99 mg ÷ 2.19 mg; Trisequens T1 table: 1.78 mg ÷ 2.18 mg; Trisequens T2 table: 1.92 mg ÷ 2.12 mg; Trisequens T3 table: 0.97 mg ÷ 1.17 mg. The proposed validated TLC-densitometric method is appropriate for quality control of Estradiol hemihydrate in commercially available tablets.

Key words: Estradiol hemihydrate, TLC, Densitometry, Tablets, analysis, Determination.

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