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Published on:30th Jan 2014
Indian journal of Pharmaceutical Education and Research, 2014; 48(1):49-55
Pharmaceutical Research | doi:10.5530/ijper.48.1.8

Development and Evaluation of Gastroretentive Microspheres of Cefixime


Authors and affiliation (s):

Syed M. Faizi*, S. R. Wasankar, P. N. Rathi, S. N. Lateef, Amol Borade and Anwar Ahmed
M. Pharm (Pharmaceutics), Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602

Abstract:

The present study aims towards the preparation and evaluation of floating microspheres of Cefixime with the main objective to prolong gastric residence time. The microspheres were prepared by the emulsion solvent diffusion method using ethyl cellulose in different concentrations. The prepared microspheres were evaluated for their percentage yield, particle size, scanning electron microscopy, drug entrapment, in-vitro buoyancy, in-vitro drug release, drug release kinetics, FTIR spectroscopy, antimicrobial and stability study. The prepared microspheres exhibited prolonged drug release (~8 hours) and remained buoyant for >8 hours. The mean particle size increased and the drug release rate decreased at higher polymer concentration. From the results we can conclude that the floating microspheres loaded with Cefixime may enhance its gastric residence time and may reduce dosing frequency.

Key words: floating microspheres, Cefixime, gastric residence time, emulsion solvent diffusion method, ethyl cellulose.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs