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Published on:Oct 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(4):703-707
Original Article | doi:10.5530/ijper.50.4.23

Study of Relative Association, Apparent Molar Compressibility and Free Length of Entacapone API in alcohols at different Frequencies


Authors and affiliation (s):

Sachin Deorao Zade, Padma Sachin Zade, Pravin J. Ganjre, Sunanda Shashikant Aswale and Shashikant Rajeshwar Aswale

Lokmanya Tilak Mahavidyalaya, Wani, Dist. Yavatmal, 445 304 (MS).

Abstract:

The values of ultrasonic velocity is measured by using ultrasonic interferometer for 0.01M solution of entacapone in methanol, ethanol, 1-propanol and 1-butanol as a solvent at 303.15 K by using frequency 2 MHz, 4 MHz and 6 MHz. This experimental data is used to explore the acoustic properties like intermolecular free length, relative association and apparent molar compressibility. From these thermodynamic and acoustic properties, the molecular interactions like solute-solute and solute-solvent occurring in solution have been interpreted with respect to change in solvent at different frequencies. It was observed that apparent molar compressibility value decreases from 2 MHz to 6 MHz in solvent Methanol to 1-butanol. Decreasing trend in Ultrasonic velocity shows less interaction between solute and solvent molecules. From 2 MHz to 6 MHz intermolecular free length increases which shows weak molecular interaction. Relative association increases from methanol to 1-butanol from increasing frequency i.e. from 2MHz to 6MHz. It shows strong solute solvent interaction.

Key words: Ultrasonic interferometer, Apparent molar compressibility, Intermolecular free length, Relative association, Molecular interaction.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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