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Published on:January 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(1):150-155
Original Article | doi:10.5530/ijper.51.1.20

Vildagliptin and Insulin Combinatorial Therapy Drug Safety Monitoring in Diabetic Rats


Authors and affiliation (s):

Priya Ebenesan1 and Mallika Jainu2*

1Department of Biochemistry, Research and Development Centre, Bharathiar University, Coimbatore – 641046, Tamil Nadu, INDIA

2Department of Biomedical Engineering, Sri SivaSubramaniya Nadar College of Engineering, Kalavakkam, Chennai -603110, INDIA.

Abstract:

Background: Type 2 Diabetes Mellitus is a long term metabolic disorder that is characterized by high blood sugar, insulin resistance, and lack of insulin. Based on the understanding of the pathogenesis of T2DM, several distinct pharmacological therapies have been developed but many of them are producing significant adverse drug reactions. Objectives: The present study helps to understand the progression of hepatic degeneration in diabetes mellitus upon treatment with vildalgliptin and insulin. This study is aimed to evaluate the toxicity of combined therapy of vildagliptin and insulin in alloxan induced diabetic rats. Methods: Adult male albino Wistar rats were distributed among 5 groups, and induced diabetes with alloxan. The alterations in glucose metabolizing enzyme activities were determined spectrophotometrically in the liver homogenate and confirmed by histological study. The hematological count has been carried out in all experimental groups to understand the toxicity of combinatorial therapy. Results: The histopathological studies showed pathological changes in the cellular architecture and microcytic hepatic nuclei. The level of haemoglobin, red blood cells and platelet count has been lowered drastically when compared to the monotherapy showing that the combinatorial therapy makes the animal anaemic. The level of lymphocytes has been considerably reduced in the combinatorial therapy showing the loss of immunity. The glucose metabolizing enzymes have been significantly altered showing the glucose metabolism is severely affected in combinatorial therapy showing it was not properly metabolized. Conclusion: The above studies have clearly proves that vildagliptin and insulin drug therapy shows toxicity on metabolic organs and blood cells. So our studies will be really helpful for developing new drugs which are devoid of adverse effects.

Keywords: Vildagliptin, Insulin, Hepatic tissues, Incretins, Adverse effects.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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