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Published on:March 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(2):295-301
Original Article | doi:10.5530/ijper.51.2.35

Investigation and Characterization of Maghemite (γ-Fe2O3) Nanoparticles and Its Cytotoxicity Studies


Authors and affiliation (s):

Mahdi Khodabakhshi, Ali Bahari

Department of Physics, Faculty of Basic Sciences, University of Mazandaran, Babolsar, IRAN.

Abstract:

Objective: The expansion of wet chemical method for the synthesis of iron oxide nanoparticles with magnetic properties is reported. Methods: Iron oxide nanoparticles were investigated in the procedure using Transmission Electron Microscopy (TEM). It has been seen that the distribution size changed by changing of Molarity precursor and heating the sample. The magnetization evaluations were performed using a Vibrating Sample Magnetometer device (VSM) to specify the magnetic answer. The Thermo Gravimetric Analyses (TGA) displayed the size-dependent weight loss of the magnetic nanoparticles. In this work, the cytotoxic activity of various samples of Maghemite on cancer cell lines HELA was studied. The in vitro cytotoxicity tests were also performed to determine the cell viability as a work of size and heat of the magnetic nanoparticles. Results: The samples c and d at T=300°C had a little magnetic hysteresis that can use in cancer cure with hyperthermia therapy method. Conclusions: These samples became amorphous and they were nontoxicity.

Key words: Magnetic properties, Maghemite, Iron oxide nanoparticles, Cell viability, Cytotoxicity.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs