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Published on:April 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(2s):s34-s39
Original Article | doi:10.5530/ijper.51.2s.47

Aluminium-eriochrome Cyanin R, A Novel Chromogen for the Spectrophotometric Determination of Pentoprazole Sodium


Authors and affiliation (s):

Pavan Kumar GVSR, Kondrotu Srinivasa Rao

Department of Chemistry, MVGR College Of Engineering (A), Vizianagaram-535005, Andhra Pradesh. INDIA.

Abstract:

A Spectrophotometric method for the determination of pentoprazole sodium in bulk and pharmaceutical formulations was developed by the authors. The method is based on the color reaction between the sample solution of the drug and a solution of aluminiumeriochrome cyanin R. the reagent was found to be unique and novel in the detection and determination of the drug. A reddish purple color solution is the resultant of the reaction between the drug and the reagent. This reddish purple colored product showed λmax at 533.5nm. Beer’s law was found to be obeyed in the concentration range 3.2-12.8 μg ml-1. Limit of detection was found to be 0.048 μg ml-1 and limit of quantification was 0.148 μg ml-1. The method was found to be sensitive, simple, easy, accurate and precise.

Key words: Pentoprazole Sodium, Eriochrome Cyanin R, Spectrophotometry, Pharmaceutical Formulations, Aluminium Chloride.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs