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Published on:April 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(2s):s40-s45
Original Article | doi:10.5530/ijper.51.2s.48

In situ cross Linked Chitosan-Gellan Gum Polyelectrolyte Complex Based Nanogels Containing Curcumin for Delivery to Cancer Cells


Authors and affiliation (s):

Hitendra Shaligram Mahajan, Priyanka Pramod Patil

R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, INDIA.

Abstract:

Objective: The objective of this study is to prepare nanogels were prepared via ionic complexation with negatively charged gellan gum. Method: Nanogel of curcumin was prepared by in situ cross linking reaction between two oppositely charged materials by green method without use of chemical cross linking agents. The prepared nanogels were characterized by Dynamic light scattering, scanning electron microscopy, differential scanning calorimetry and X- Ray diffractometry. Results: The prepared formulation had average particle size of 226 nm with polydispersity index of 0.3. The curcumin loaded nanogel demonstrated sustained release for 20 h. The prepared nanogels were hemocompatible and cyctocompatible as revealed by hemocompatibility and MTT assay respectively. Conclusion: All results confirmed that these nanogels can be used for cancer treatment.

Key words: Nanogel, Chitosan, Gellan gum, Curcumin, Cancer.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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