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Published on:30th Jan 2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(1):69-74
Pharmaceutical Research | doi:10.5530/ijper.48.1.11

Development and Evaluation of Mucoadhesive Buccal Tablets of Ketorolac Tromethamine


Authors and affiliation (s):

Monica RP Rao* and Priyanka Sadaphule
Department of Pharmaceutics, AISSMS College of Pharmacy, Kennedy Road, Near R.T.O. Pune-411001

Abstract:

Buccal route offers excellent opportunities and potential advantages for systemic drug delivery as compared to per-oral administration. The objective of this study was to prepare mucoadhesive tablets of Ketorolac tromethamine in order to circumvent the gastric irritation associated with the drug. The tablets were prepared using various hydrophilic polymers like Hydroxy propyl methyl cellulose K4M (HPMC), Carbopol 934P (CP) and xanthan gum singly and in combination, by direct compression followed by coating with impervious backing layer of ethyl cellulose to obtain unidirectional release of drug. Tablets were evaluated for physical properties, drug content, swelling index, mucoadhesion, and in vitro dissolution studies. The formulation containing CP-HPMC combinations were found to be uniform in thickness, weight, drug content and adequate mucoadhesive strength and swelling index. The higher swelling index for tablets of CP-HPMC combinations may be attributed to the relatively higher hydrophilicity of carbopol. Histological studies revealed no damage to buccal mucosa. It can be concluded that buccal route is a promising alternative for administration of Ketorolac tromethamine

Key words: Ketorolac tromethamine, mucoadhesive, swelling index, direct compression.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs