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Published on:July 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4):613-619
Original Article | doi:10.5530/ijper.51.4.91

Simultaneous Determination of Linezolid and Levamisole Hydrochloride in a Fixed Dose Combination


Authors and affiliation (s):

Lalit Kumar, Yugvijay Singh Yadav, Mahalaxmi Rathnanand*

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar 576 104, Manipal, Udupi, Karnataka, INDIA.

Abstract:

Background: The combination of antibiotics with an immune-stimulant can be used for the prevention of antimicrobial resistance. Multilayer tablets of linezolid and levamisole hydrochloride can be a solution of this problem. Objective: Aim of the present study was to High Performance Liquid Chromatography method development and validation as per the International Council for Harmonisation guidelines for analysis of both the drugs simultaneously in a single unit dosage form. Methods: Ammonium acetate and acetonitrile in the ratio 65:35 (%v/v) was used as mobile phase. Ultra violet detection was carried out at 236 nm and flow rate was kept as 0.9 mL/min. Results: Linezolid and levamisole hydrochloride were found at 4.61 min and 6.45 min retention times, respectively. Conclusion: The study confirmed that the present method can be used for routine simultaneous analysis of linezolid and levamisole hydrochloride.

Key words: HPLC, Levamisole hydrochloride, Linezolid, Antibacterial resistance, Antimicrobial resistance.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs