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Published on:30th Jan 2014
Indian Journal of Pharmaceutical Education and Research, 2013; 47(4):31-38
Pharmaceutical Research | doi:10.5530/ijper.47.4.5

Synthesis and preliminary evaluation of a focused chalcone library for anti-inflammatory activity


Authors and affiliation (s):

Ranganathan Balasubramanian*,1, Hiba Iqbal1, Rachana Vijaya Gopal1 and C Baby2
1Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham University, Health Sciences
Campus, Kochi-682041, Kerala, India
2 Sophisticated Analytical Instrumentation Facility, Indian Institute of Technology, Madras, Chennai-600036, Tamil Nadu, India

Abstract:

A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationally designed leading to a focused library of ligands 4a-j with ring-A substitution. Subsequent to drug-likeness and druggability assessments, the library members were synthesized in optimal yields and their structures were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Screening for anti-inflammatory activity revealed that most of the compounds were quite effective in containing inflammation with compound 4b being the most promising derivative.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs