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Published on:July 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(3s):s159-s162
Original Article | doi:10.5530/ijper.51.3s.4

The Effects of Ginger Extract and Diazepam on Anxiety Reduction in Animal Model


Authors and affiliation (s):

Fatemeh Fadaki1, Mehrdad Modaresi2*, Ilnaz Sajjadian1

1Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, IRAN.

2Department of Animal science, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, IRAN.

Abstract:

Objective: Anxiety disorders are from common disorders of human. Drug treatments have side effects, and searching new ways with fewer side effects is inevitable. Ginger is a medicinal plant with many therapeutic effects. Methods: In current study the effects of ginger extract and diazepam on anxiety reduction of laboratory mice were investigated. Sixty female mice (25-30g) were divided into six groups including control, anxiety, diazepam and 50, 100 and 200 mg/kg extract doses. After receiving the last dose, all groups except control group were placed in dark box to enforce anxiety. Next, anxiety evaluation test was carried out using plus elevated maze. The number of open and close arms were considered as anxiety indices. Results: According to results, ginger extract reduced anxiety in all doses in proportion to control and diazepam groups. Also, movement activity was increased in 200 mg/kg dose significantly (p<0.05). Conclusion: Therefore, ginger extract in 200 mg/kg dose can be an appropriate replacement for diazepam to reduce anxiety symptoms.

Key words: Ginger, Anxiety, Diazepam, Plus elevated maze, Mice.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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