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Published on:July 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4):656-663
Original Article | doi:10.5530/ijper.51.4.97

Calprotectin Complex Interactions with Phytoquinolines and New Target Binding Alternates Calprotectin complex and Phytoquinolines


Authors and affiliation (s):

Muthukrishnan Suriyavathana* and Meleveetil Vidhya

Department of Biochemistry, Periyar University, Salem-11, Tamil Nadu. INDIA.

Abstract:

Objective: S100 proteins, the low molecular weight calcium binding proteins, have ‘EF hand’ type conformation. They are identified as markers for various diseases. A member of S100 protein family, S100A9 is involved, in performing important biological functions, by coordinating with S100A8. S100A9 targeted interactions of quinoline-3- carboxamides, differentiates quinoline derivative interaction among varying single point substituents. Inhibition of protein interaction with many important biological markers as RAGE, TLR4/MD2 and others, was accomplished by quinoline-3-carboxamides. Methods: Two quinoline derivatives identified from Toddalia aculeata are analysed for their molecular and ligand properties. Results: Toxicity analysis, show ADMET properties of phytoquinolines, to be supportive. Molecular binding with S100A9 and its heteromer formed with S100A8, are found analogous to binding, with substituted quinoline-3- carboxamides.Among the various ligands used, a phytoquinoline derivative, and methyl substituted quinoline-3-carboxamide, show most stable interactions. Conclusion: This study proposes the use of compounds from source, as potential ligands to target marker S100A9 and its heterodimer.

Key words: Quinoline, Calprotectin, Molecular Interaction, Ligand, ADMET.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs