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Published on:July 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4):713-721
Original Article | doi:10.5530/ijper.51.4.105

Quality Standardization and Nephroprotective Effect of Garcinia pedunculata Roxb. Fruit rind


Authors and affiliation (s):

Ravi Mundugaru1, Senthil Kumar Sivanesan2, Padmaja Udaykumar3, Febin Joy4, Sunil Kumar Koppala Narayana5*, Lekshmi Rajakrishnan6, Ahmed Hamad AlFarhan7, Thomas Jacob7, Rajakrishnan Rajagopal7, Sameh Mohammed Hisham7

1Department of Pharmacology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, I Karnataka, NDIA.

2Department of Research and Development, Saveetha University, Thandalam, Chennai, Tamil Nadu, INDIA.

3Department of Pharmacology, Father Muller Medical College, Mangalore, Karnataka, INDIA.

4Department of Dravyaguna, Muniyal Institute of Ayurveda Medical Sciences, Manipal, Karnataka, INDIA.

5Department of Pharmacognosy, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, Karnataka, INDIA. Current: Department of Pharmacognosy, Siddha Central Research Institute, Arumbakkam, Chennai, Tamil Nadu, INDIA.

6Department of Botany and Biotechnology, MSM College, Kayamkulam, Kerala, INDIA.

7Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, SAUDI ARABIA.

Abstract:

Introduction: Fruit rind of Garcinia pedunculata is one of the important medicinal plant and a condiment used in Indian kitchen. In spite of many medicinal properties ascribed to this species, less of pharmacological studies are carried out on this species. The objective of present study was to determine the quality standards of the fruit rind followed by evaluation of nephroprotective activity of aqueous extract in cisplatin induced nephrotoxicity. Materials and Methods: Macro-microscopic, physico-chemical, preliminary phytochemical and HPTLC studies were carried out following pharmacopoeial procedures. On 7th days an hour after treatment with group specific drugs, cisplatin 20mg/ kg was injected intraperitonially to all groups except normal control mice. Nephrotoxicity was assessed by serum biochemical, antioxidant and histological changes in kidney after 72h of cisplatin injection. Results and Discussion: Pharmacopoeial tests revealed authenticity and quality indicating standards for the fruit rind. Single intraperitonial injection of cisplatin significantly elevated serum urea, creatinine and lipid peroxidation in kidney tissue compared to the control group. The drug has exhibited necrotic changes in the tubular epithelium, edematous changes in the interstitial tissue and focal cell infiltration. These changes were significantly reduced with AFGP administration and considerably reversed the histological changes caused by cisplatin injection. Conclusion: The study concludes that the quality standardized fruit of Garcinia pedunculata has nephroprotective activity.

Key words: Antioxidant, Cisplatin, Nephroprotective, Serum Creatinine, Quality Standards.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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