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Published on:July 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4):740-747
Original Article | doi:10.5530/ijper.51.4.108

A Study on Antimicrobial Evaluation of Newly Synthesized Antipyrin Analogues


Authors and affiliation (s):

Sahoo Jyotirmaya1*, Paidesetty Sudhir Kumar2

1Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar 752101, Odisha, INDIA.

2Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, Odisha, INDIA.

Abstract:

The antipyrinyl derived molecules are a versatile building blocker organic compounds and used in medicinal drug research. A versatile range of hybrid molecules have been synthesized by diazotization of 4-aminoantipyrin and further substituted with six different coupling components. The structures of the synthesized compounds have been confirmed by different spectral techniques. The antimicrobial activity of the synthesized molecules is investigated by agar well diffusion method against a wide range of microbial strains. The results of the antimicrobial activities of the novel synthesized molecules are statistically interpreted by dunnet post hoc test. It is found to be observed that the compound 4-[(4-Hydroxy-2-oxo-2H-chromen-3-yl)diazenyl]-1, 5-dimethyl-2-phenyl- 1H-pyrazol-3(2H)-one (4a) showed significant antimicrobial activity against S. flexneri, K. pneumonia, M. luteus, S. mitis, B. subtilis and S. aureus in comparison to standard ampicillin. The solvatochromic study of the synthesized compounds revealed that the compound 4-((2, 4-dihydroxyphenyl) diazenyl)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (4d) 4-((2-hydroxynaphthalen-1-yl) diazenyl)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (4e) showed good bathochromic shift in comparison to other solvents used. These novel synthesized azo molecules may be suggested for new establishment chemical class of antimicrobial agents and to create an opportunity in new drug discovery and medicinal research.

Key words: Diazotization, Antimicrobial, Acute Toxicity, Solvatochromic.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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