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Published on:20 sep 2013
Indian Journal of Pharmaceutical Education & Research, 2013; 47(2):123-128
Research Article | doi:Not Applicable

Development and Characterization of Artemether Loaded Solid Lipid Nanoparticles


Authors and affiliation (s):

Nisha Raina1, Amit K. Goyal1, Pillai C.R2 and Goutam Rath*1
1Department of Pharmaceutics, ISF College of Pharmacy, Ghal Kalan, Ferozpur Road, Moga
2National Institute of Malaria Research (ICMR), Sector 8, Dwarka, DELHI-110077

Abstract:

Malaria is a widespread infectious disease of humans but emergence of resistance has worsened the scenario. Therefore it is important to use novel carriers for treatment of malaria due to their advantages over conventional. Recently, solid lipid nanoparticles (SLNs) have recently received considerable attention as alternative drug delivery carrier. The objective of the present investigation was to explore the potential of SLNs for the intravenous delivery of artemether (ARM). SLNs were prepared using hot melt method. The SLNs were evaluated for particle size, shape, zeta potential, poly dispersity index (P.D.I.), entrapment efficiency, in vitro drug release and in vitro hemolysis. The antimalarial activity of ARM loaded SLNs and marketed formulation was evaluated in Plasmodium berghei infected mice. Scanning electron microscopy (SEM) revealed the optimized formulation was found to be smooth, spherical and non- aggregated. Zeta potential and P.D.I of optimized formulation was found to be -31.45 mV and 0.025 respectively. SLNs containing artimether showed lesser haemolysis but better anti malarial activity comparable to free drug and marketed formulation in preventative stage. Artemether loaded solid lipid nanoparticles prepared by hot melt method is a significant delivery system for targeting liver cells for the treatment of malaria disease.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs