Evaluation of Antiurolithiatic Potentials of Hydro-Alcoholic Extract of Cucumis sativus L.

Abstract:

Introduction: Cucumis sativus fruits are claimed for their antiurolithiatic activity in traditional system of medicine. Materials and Methods: Present study was undertaken to evaluate lithotryptic effect using hydro-alcoholic extract of Cucumis sativus (HCS). Ethylene glycol (0.75% v/v) was used to induce calculi in Wistar albino rats. Assessed various parameters like, Biochemical, Histopathological and routine urine analysis. Results: Treatment with preventive and curative doses of HCS was found to exert dose dependent antiurolithiatic action. Increased urine volume in HCS treated groups as compared to diseased group was indicative of diuretic property. Elevated calcium, phosphate and oxalate levels in diseased group animal were found to be decreased in animals treated with HCS. Increased levels of serum creatinine, BUN and uric acid were considerably brought down towards normal values in proportion to HCS doses administered. Histopathology of kidney reveals severe renal damage due toperformed crystals. Animals treated with HCS showed remarkable recovery, suggestive of prevention of nucleation and aggregation of stone forming components. Conclusion: It can be concluded that, results are supportive to claims made. The exact mechanism of antiurolithiatic effect may further needs to be studied.

Key words: Cucumis sativus, Antiurolithiatic, Ethylene glycol (0.75 % v/v), Diuretic, Cystone, Kidney stone.