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Published on:December 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4s):s623-s630
Original Article | doi:10.5530/ijper.51.4s.91

In-vitro Evaluation of Antifungal Activity of Ganoderma lucidum Against the Biofilm Producing Candida species


Authors and affiliation (s):

Naveen kumar C1*, Jayalakshmi G2, Chidambaram R3, Srikumar R4

1Ph.D Research Scholar, Sri Lakshmi Narayana Institute of Medical Sciences, Osudu Lake, Koodapakkam, Pondicherry, INDIA.

2DEAN, Sri Lakshmi Narayana Institute of Medical Sciences, Osudu Lake, Koodapakkam, Pondicherry, INDIA.

3Director of Research, Sri Lakshmi Narayana Institute of Medical Sciences, Osudu Lake, Koodapakkam, Pondicherry, INDIA.

4Research Associate, Sri Lakshmi Narayana Institute of Medical Sciences, Osudu Lake, Koodapakkam, Pondicherry, INDIA.

Abstract:

Background: Bioproducts of mushrooms Ganoderma lucidum have multi beneficial effects for human welfare. Objectives: The aim of the present study was to evaluate antifungal activity of Ganoderma lucidum against the biofilm producing fungi. In this current study it carries 100 Candida species which forms biofilms were collected from the Immunocompromised and Immuno Suppressive patients. Methods: The fruit bodies of Ganoderma lucidum were collected and done the extraction at various concentrations with the help of Dimethyl sulfoxide (DMSO) and Methanol. The various concentrations of the extracts were applied by Proteinase and phospholipase enzyme secretion assay, Minimum Inhibitory Concentration (MIC) - XTT Assay and Minimal Fungicidal Concentration (MFC). Results: Our results showed the MIC and MFC of DMSO extract were shows highest significant value (P<0.05) against the antifungal activity than the methanolic extract of the Ganoderma lucidum among the various biofilm producing candida species. Conclusion: So we can be conclude that DMSO extract of the Ganoderma lucidum shows high significant factor against the various disease causing Candida species and its biofilm.

Key words: Ganoderma lucidum, Biofilms, Candida species, Proteinase, Phospholipase, DMSO and Methanol extracts.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs