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Published on:December 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(4s):s783-s789
Original Article | doi:10.5530/ijper.51.4s.113

Development and Validation of Inductively Coupled Plasma Atomic Emission Spectroscopy [ICP-AES] Analytical Method for Estimation of Cisplatin in Biological Samples


Authors and affiliation (s):

Shruti Akshay Wagle1*, Darshana Jain2, Sudha Rathod1, Rajani Athawale3, Amrita Bajaj4

1Oriental College of Pharmacy, Sector 2, Plot No 3, 4, 5, Sanpada (W), Navi Mumbai, Maharashtra, INDIA.

2C.U.Shah College of Pharmacy, S.N.D.T Women’s University, Santacruz (W), Mumbai, Maharashtra, INDIA.

3Principal K.M Kundnani College of Pharmacy, Plot No. 23, Jote Joy Building, Rambhau Salgaonkar Road, Cuffe Parade, Mumbai, Maharashtra, INDIA.

4SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, V.M Road, Vile Parle (W), Mumbai, Maharashtra, INDIA.

Abstract:

Objective: Cisplatin, a popular anti-neoplastic agent is employed as a first line treatment for variety of cancers. Majority of the analytical methods reported for Cisplatin are either complex or not suitable for routine analysis of the drug. Hence, there is a need for development of suitable analytical technique like ICP-AES for quantitation of Cisplatin in complex matrices and biological samples. Methods: Cisplatin was analyzed in the present study based on its single step conversion to platinum metal with aqua regia. Results: The developed method was validated and was found to be linear in the range of 0.375 to 15 μg/ml with a regression coefficient of 0.992. The percent recoveries of Cisplatin from plasma and tissue samples ranged from 95 to 99%. Discussion: A simple, low cost, sensitive, one step ICP-AES technique was developed and validated for bioanalytical estimation of Cisplatin. Key words: Cancer, Cisplatin, ICP-AES, Platinum.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs