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Published on:January 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(2):248-254
Original Article | doi:10.5530/ijper.52.2.28

Evaluation of Diuretic and Saliuretic Potential of Beta vulgaris (Beet Root) at Different Doses


Authors and affiliation (s):

Sana Sarfaraz1, Rahila Najam2

1Department of Pharmacy, Jinnah University for Women, Karachi, Karachi, PAKISTAN.

2Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, PAKISTAN.

Abstract:

Background: Natural foods are presently being evaluated for their pharmacological activity. They are comparatively safer and possess fewer adverse effects. Objective: The current study was designed to evaluate the diuretic effect of different doses of lyophilized Beta vulgaris. Methodology: Aqueous solution of Beta vulgaris at doses of (500 mg/kg and 1000 mg/kg) was administered to rats. Furosemide 40 mg/70kg and distilled water were used as standard and control respectively. Metabolic cage was used for evaluation of diuretic effect. Diuretic effect was observed 24 h after orally administering the drugs. The urine output, pH, sodium, potassium, chloride and phosphorus were measured. Result: Beta vulgaris showed highly significant (p<0.001) diuretic activity as compared to control. Both doses of Beta vulgaris also showed highly significant (p<0.001) effect on sodium, potassium, chloride and phosphorus excretion as compared to control. Both doses of Beta vulgaris showed alkalization of urine. Conclusion: From our study we came to conclude that Beta vulgaris at 500 mg/kg can be used as a diuretic agent where as at 1000 mg/kg dose it not only possesses diuretic potential but also doesn’t cause hypokalemia and is also very useful in treating hyperphosphatemia as it increases excretion of phosphate in urine.

Key words: Chloride, Diuretics, Metabolic cage, Phosphorus, Potassium and Sodium.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs