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Published on:16 Nov 203
Indian Journal of Pharmaceutical Education and Research, 2013; 47(3):42-48
Pharmaceutical Research | doi:10.5530/ijper.47.3.7

Design and In Vitro Evaluation of Pentoxifylline- Polyelectrolyte Complex Tablets


Authors and affiliation (s):

Teresa G Poozhikanadakel*, N.R. Charyulu, N.M. Harish and B. Vishalakshi
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Mangalore-575018, Karnataka, India.

Abstract:

The study evaluates the possibility of using polyelectrolyte complexes (PECs) in the form of mucoadhesive matrix tablets to achieve a prolonged drug release profile of Pentoxifylline suitable for peroral administration. PECs were formed by different ratios and combination of polymers (chitosan–alginate, chitosan-carbopol and chitosan– carrageenan) and were dried by lyophilisation. Characterization was performed by Fourier Transform-Infrared (FT-IR) spectroscopy and X-Ray Diffraction (XRD) studies. The tablets were formulated by direct compression method. The influence of polymer ratio on drug release was studied by swelling index and dissolution studies and ex-vivo studies gave the bioadhesive strength. The formulation were subjected to accelerated stability testing as per ICH guidelines. The release data were examined kinetically. All the lyophilized PECs had some degree of prolonged release properties. The chitosan-carbopol complex matrices CC4 and CC3 were the best candidates compared to the other systems in prolonging the drug release profile of Pentoxifylline.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs