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Published on:June 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(3):480-491
Original Article | doi:10.5530/ijper.52.3.56

Anti-Leishmanial Activity of Flavanone Analogues Targeting Pteridine Reductase


Authors and affiliation (s):

Afroze Alam1,2*, Vinay Pandit3, Shailendra Kumar4, Kamlesh Kumar Naik5, Mahfoozur Rahman6, Mohan Lal Verma2*

1Narayan Institute of Pharmacy, Jamhar, Rohtas (Sasaram), Bihar, INDIA.

2Narayan Medical College and Hospital, Jamhar, Rohtas (Sasaram), Bihar, INDIA.

3Laureate Institute of Pharmacy, SH 22, VPO Kathog, Kangra, Himachal Pradesh, INDIA.

4Govt. Pharmacy Instutute, Agam kuan, Patna, Bihar, INDIA.

5Nandha College of Pharmacy, Perundurai Main Road, Erode, Tamil Nadu, INDIA.

6Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences (SHIATS), Allahabad, Uttar Pradesh, INDIA.

Abstract:

Objectives: The aim of the study is to develop new synthetic anti-leishmanial agents as flavanone analogues, which should have low toxicity with noticeable yield. Methodology: The starting materials for the synthesis of test compounds were 2’-hydroxypropiohenones, 2’-hydroxyacetophenone and substituted benzaldehyde. Test compounds were synthesized by three steps reaction starting from condensation, cyclization and reduction to yield 3-substituted flananone analogues. The synthesized compounds were screened by in vitro anti-leishmanial assay against promastigotes of L. donovani. Result: A series of flavanone analogues have been synthesized using cobalt (II) phthalocyanine and NaBH4 in the equimolar ratio of the reactant with noticeable yield. The structures of the test compounds were elucidated and established by U.V. IR, 1H-NMR, 13C-NMR and mass spectrometry. The synthesized compounds were screened by in vitro antileishmanial assay against promastigotes of L. donovani. Conclusion: Most of the compounds exhibited moderate leishmanicidal activity, while some compounds such as 4b, 10b, 5b, and 3a have shown promising antileishmanial activity against promastigotes of L. donovani.

Key words: Antileishmanial activity; Cobalt (II)phthalocyanine; Flavanone derivatives; L. donovani; Promastigotes.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs