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Published on:August 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(4s):s63-s70
Original Article | doi:10.5530/ijper.52.4s.77

Development of a Validated Stability Indicating Liquid Chromatographic Method for the Determination of Pterostilbene


Authors and affiliation (s):

Mukthinuthalapati Mathrusri Annapurna*, Bukkapatnam Venkatesh, Gunnam Ravi Teja

Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, Andhra Pradesh, INDIA.

Abstract:

Introduction: Pterostilbene, a stilbenoid possess diversified pharmacological activities. In the present study, a stability-indicating liquid chromatographic method was proposed for the determination of Pterostilbene in pharmaceutically available formulations. Materials and Methods: The chromatographic separation was achieved on Phenomenex C8 type column as stationary phase. UV detection was carried out at 219 nm. Pterostilbene was subjected to various stress conditions such as acidic, alkaline, oxidative, thermal and photolytic degradations. Results:The drug was found to be sensitive towards acidic and alkaline stress conditions. The proposed method was validated as per the ICH guidelines and successfully applied to the available marketed formulations. Conclusion: The proposed method is selective, specific, robust and can be applied for the assay of pharmaceutical dosage forms.

Key words: Pterostilbene, Stability-Indicating, RP-HPLC, Validation, ICH guidelines.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs