Home | Articles
Published on:16 Nov 2013
Indian Journal of Pharmaceutical Education and Research, 2013; 47(3):31-41
Pharmaceutical Research | doi:10.5530/ijper.47.3.6

Development of Valproic Acid Niosomal in situ Nasal Gel Formulation for Epilepsy


Authors and affiliation (s):

Shilpa P. Chaudhari and Vibhavari M. Chatur
Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune-33.

Abstract:

Valproic acid is an anti-epileptic drug used in the treatment of epilepsy and seizures. The study was designed with three aims. Firstly, to enhance the solubility and bioavailability of BCS class II drug Valproic acid; secondly, to ease administration of the formulation to the epileptic patient, during an attack, and thirdly, to reduce the dose of drug for long-term treatment. In the culmination of this study, an anti-epileptic drug loaded (Valproic acid) niosomal gel for nose-to-brain-delivery using thermosensitive polymer PF 127 was formulated, which can be a controlled dose to the patient. Niosomal formulations were optimized by altering the proportions of range of Tween and Span. The formulations were prepared by ether injection method. The formulation was then evaluated for morphological characterization, encapsulation efficiency, and viscosity. Valproic acid niosomes formulated with Tween 80 and Span 60 were found to entrap high amounts of drug. Further the niosomal gel was prepared by using various concentrations of PF 127 and were optimized at effective concentrations and studied for gelation temperature, melting temperature and heat of enthalpies, mucoadhesive strength, gel strength and showed satisfactory results. The niosomes entrapped in-situ nasal gel formulations showed sufficient quantity of in-vitro drug release through the gel across the goat’s nasal mucosa. In histopathological study no effect of surfactant was seen; neither had the formulations caused any damage to the nasal tissue. Hence we can conclude that the niosomal in-situ nasal gel system can be considered as a promising approach for the anti-epileptic drug Valproic Acid.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
11 + 4 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
1 + 17 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs