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Published on:November 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(4s2):S237-S245
Original Article | doi:10.5530/ijper.52.4s.103

Evaluation of Comparative Immunomodulatory Potential of Solanum xanthocarpum Root and Fruits on Experimental Animal


Authors and affiliation (s):

Ravindra Kumar Pandey1,2, Shiv Shankar Shukla2, Anurekha Jain2, Avijeet Jain2, Vipin Bihari Gupta2, Lokesh Deb2,3,*

1Columbia Institute of Pharmacy, Raipur-492001, Chhattisgarh, INDIA.

2BRNSS-Contract Research Center, B. R. Nahata College of Pharmacy, Mandsaur-458001 Madhya Pradesh, INDIA.

3Institute of Bio resources and Sustainable Development (An autonomous Institute of Department of Biotechnology, Government of India) – Sikkim Centre (IBSD-SC), 5th mile, NH-10A, Near Metro Point, Tadong, Gangtok -737102, East Sikkim, Sikkim, North East India, INDIA.

Abstract:

Aim: This study was aimed to justify the scientific basis in folklore use of Solanum xanthocarpum (solanaceae) as an Immunomodulatory agent in India. Materials and Methods: The ethanol and aqueous extracts of S. xanthocarpum fruit (SXE-1 and SXA-1), root (SXE-2 and SXA-2) and whole plant (SXE-3 and SXA-3) were evaluated for immunomodulatory activity by using cold water swim endurance stress test, delayed type hyper sensitivity reaction, carbon clearance test and CCl4 induced oxidative stress model on experimental animals. The solasodaine content in S. xanthocarpum bioactive test samples were quantified by HPLC to establish phyto-pharmacological relationship. Results: The 200 mg/kg/day p.o. dose of test samples were showed significant changes in swimming survival time and at same doses test samples were significantly increased hypersensitivity, decrease in carbon clearance and reduced oxidative stress. Where, SXE-1 and SXA-1 exhibited maximum degree of immunomodulatory effect compared to SXE-2, SXA-2, SXE-3, SXA-3 and respective standard drugs used in this study. The hematological, biochemical and histopathological studies were supported respective results of the test samples. The solasodaine content in SXA-1 (1.146%), SXE-1 (0.894%), SXE-2 (0.643%) and SXA-2 (0.620%) were estimated by HPLC. Conclusion: These observations established the traditional claim and thus S. xanthocarpum could be a potent immunomodulatory agent for use in near future. The immunostimolatory effect may be due to presence of solasodaine in S. xanthocarpum extracts.

Key words: S. xanthocarpum, Solasodaine, HPLC, Immunomodulatory, CCl4.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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