Evaluation of Neuroprotective Potential of Some Newly Synthesized Benzopyran-2-One Derivatives in Swiss Albino Mice

Abstract:

Background: Present study was carried out to evaluate neuroprotective activity of newly synthesized Benzopyran-2-one derivatives. Methods: Three compounds namely 7-(2-(o-furan)-phenyl thiazolidinyl)-4-methyl benzopyran-2-one (FPTMB), 7-(2-(N,N dimethyl)-phenyl thiazolidinyl)-4-methyl-benzopyran-2-one (DPTMB) and 7-(2-(p-hydroxy)- phenyl thiazolidinyl)-4-methyl-benzopyran-2-one (HPTMB) were assessed for their effects on Central Nervous System (CNS) using a series of established pharmacological tests including evasion test for anxiolytic activity, actophotometer test for spontaneous motor activity (SMA), rotarod test for skeletal muscle relaxation and pentylenetetrazole (PTZ) induced convulsant model for anti-convulsant activity followed by Eddy’s hot plate and Haffner’s tail clip method for analgesic activity. Results: These derivatives were found to produce symptoms of CNS depression in conscious mice, viz. significant reduction in SMA and exploratory behavior by evasion test and skeletal muscle relaxation and showed a significant prolongation of latency and reduced duration of convulsions induced by PTZ. Further, these test compounds failed to show a significant anti-nociceptive activity evaluated by centrally acting analgesic models i.e., Eddy’s hot plate and Haffner’s tail clip methods. Conclusion: It may be concluded that all three derivatives possess anxiolytic activity, SMA, skeletal muscle relaxation and anti-convulsant activity but do not possess analgesic activity.

Key words: Benzopyran-2-one derivatives, Actophotometer, Eddy’s hot plate, Evasion test, Epilepsy.