Home | Articles
Published on:16 Nov 2013
Indian Journal of Pharmaceutical Education and Research, 2013; 47(3):49-55
Pharmaceutical Research | doi:10.5530/ijper.47.3.8

Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Superdisintegrants


Authors and affiliation (s):

Rajnikant M. Suthar1, Narendra P. Chotai*1 and Digesh D. Shah2
1A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, PO Box No.19 Motabazar, Vallabh Vidyanagar-388120,
Anand, Gujarat, India.
2Sanofi Aventis Pharmaceuticals Ltd. Ankleshwar, Gujarat, India.

Abstract:

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. The aim of the present investigation was to prepare solid dispersion (SD) of OSH using superdisintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. SD of drug using superdisintegrants like croscarmellose sodium (CCS), crospovidone (CP), sodium starch glycolate (SSG), and low substituted hydroxy propyl cellulose (L-HPC) respectively as carriers was prepared by solvent evaporation method. The prepared SD formulations were characterized by equilibrium solubility, fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and dissolution study. FTIR spectra revealed no chemical interaction between the drug and superdisintegrants. XRPD and DSC data indicated that OSH was in the amorphous form, which explains the better dissolution rate of the drug from its solid dispersions. Various batches of FDTs (F1-F10) were prepared using selected SD formulation of drug and carrier (1:3 ratio) and evaluated for various physical parameters and drug release study. The batch containing SD formulation in CP (F3) showed fastest disintegration (3.22s), least wetting time (10.5s) and higher dissolution (97.98% drug release in 30 min). In conclusion, FDTs of OSH prepared using SD with CP seems to be promising formulations.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
6 + 12 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
13 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs