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Published on:January 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(1):171-177
Original Article | doi:10.5530/ijper.53.1.22

Release of Doxorubicin’s Active Ingredient from the Hydrogels Derived from Acrylamide and Their Biological Functions


Authors and affiliation (s):

Sema Misir1, Ceylan Hepokur1, I. Afşin Kariper2

1Faculty Of Pharmacy, Biochemistry Department, Sivas Cumhuriyet University, Sivas, TURKEY.

2Erciyes University, Education Faculty Primary Education, Science Education Department, Kayseri, TURKEY.

Abstract:

Poly (HEMA/acrylamide/ methyl methacrylate) (PHAM) and Poly (Acrylamide/ methyl methacrylate)(PAM) polymers were synthesized for using in the release of Doxorubicin drug. Poly (HEMA/acrylamide/methyl methacrylate) (PHAM) and Poly (Acrylamide/methyl methacrylate) (PAM) composite hydrogels were prepared by a radical addition reaction in aqueous media formed by HEMA, acrylamide, and methacrylamide, with the presence of N,N’-methylenebisacrylamide. The characterization of the polymer was performed by FTIR analysis. Swelling and drug absorption properties of the polymers were analyzed in distilled water. Polymers’ toxic effects were investigated by XTT assay. It has been observed that the entire drug, which was added to the solution with 1 g of polymer, was absorbed for 3.5 h. The absorption of these polymers was found quite high. PHAM polymer showed >800% swelling and PAM polymer showed >600% at 600 min. PHAM polymer was less toxic than PAM polymer. These results, this new polymer is very suitable for the release of Doxorubicin drug.

Keywords: Doxorubicin, Poly(HEMA/acrylamide/methyl methacrylate), Poly(Acrylamide/ methyl methacrylate), Drug release.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs