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Published on:February 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(2):330-333
Original Article | doi:10.5530/ijper.53.2.42

Clinical Effects of Pantoprazole and Octreotide in Upper Gastrointestinal Hemorrhage


Authors and affiliation (s):

Yong Wang1, Fei Deng2*

1Department of Gastroenterology, Hanchuan People’s Hospital, Xiaogan, Hubei, CHINA.

2Department of Respiratory Medicine, Hanchuan People’s Hospital, Xiaogan, Hubei, CHINA.

Abstract:

Objective: This study aimed to discuss the clinical effects of pantoprazole and octreotide in upper gastrointestinal hemorrhage. Methods: A total of 114 patients with upper gastrointestinal hemorrhage admitted in our hospital from April 2016 to June 2017 were chosen and divided into control and experimental groups by lottery method. The control group (n=57) was treated with pantoprazole and the experimental group (n=57) was treated with pantoprazole+ octreotide. The therapeutic effect, occurrence rate of untoward effects, hemostatic effects at 24 and 72 h, blood-transfusion volume, hemostatic time and rehemorrhage rate at 48 h of the two groups were compared. Results: Compared with the control group, the experimental group exhibited significantly higher total therapeutic and hemostatic effects at 24 h, as well as lower occurrence rate of untoward effects and hemostatic effects at 24 h. Statistically significant differences were observed between the control and experimental groups (P<0.05). The experimental group had greater blood-transfusion volume, shorter hemostatic time and higher rehemorrhage rate at 48 h (P<0.05). Conclusion: The pantoprazole+ octreotide therapy exerted outstanding clinical effects on upper gastrointestinal hemorrhage. This combined therapy can decrease the occurrence rate of untoward effects and bloodtransfusion volume, reduce hemostatic time and prevent recurrent bleeding, thereby being worthy of clinical use and promotion.

Key words: Octreotide, pantoprazole, Upper gastrointestinal hemorrhage

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs