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Published on:April 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(2s):s18-s28
Review Article | doi:10.5530/ijper.53.2s.45

Mucoadhesive Nanoparticles: A Roadmap to Encounter the Challenge of Rapid Nasal Mucociliary Clearance


Authors and affiliation (s):

Chandrakantsing Vijaysing Pardeshi1,*, Abhijeet Dattatraya Kulkarni1, Raju Onkar Sonawane1, Veena Shailendra Belgamwar2, Prashant Jagannath Chaudhari3, Sanjay Javerilal Surana4

1Department of Pharmaceutics, Industrial Pharmacy Laboratory, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, INDIA.

2Department of Pharmaceutical Sciences, R.T.M. Nagpur University, Nagpur, Maharashtra, INDIA.

3Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, INDIA.

4Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, INDIA.

Abstract:

The modulation of mucoadhesion at the nanoscale is a very challenging task before the formulation scientists. Mucoadhesive nanoparticles are endowed with distinct properties such as increased residence, intimate contact of mucoadhesive dosage form at the mucosal surface and reproducible drug absorption. Large surface area, porous endothelial membrane, high total blood flow, ready accessibility, rapid onset of action, low enzyme level compared to gastrointestinal tract and avoidance of hepatic first pass metabolism are few of the major reasons for preferred drug delivery across the nasal mucosal membrane. There is a limited systematic summarized literature is available which could outline the potential of mucoadhesive nanoparticles for intranasal administration and present review could be an excellent platform to fulfill the voids. The authors put very enthusiastic opinion that the nasal mucoadhesive nanocarriers would meet the criteria set by regulatory authorities and soon such formulations would be available to accomplish the healing desires of the community, provided a successful execution of extensive clinical research with encouraging outcomes.

Key words: Nanomedicine, Nanoparticles, Mucoadhesion, Intranasal, Drug delivery.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs