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Published on:April 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(2s):s74-s81
Original Article | doi:10.5530/ijper.53.2s.51

Formulation, Development and Evaluation of Nifedipine Emulgel for Treatment of Anal Fissures Using Polymeric Emulsifiers


Authors and affiliation (s):

Om Shelke1*, Amol Kulkarni2

1Faculty of Pharmacy, Pacific Academy of Higher Education and Research, Udaipur, Rajasthan, INDIA.

2Dattakala College of Pharmacy, Swami-Chincholi, Daund, Pune, Maharashtra, INDIA.

Abstract:

Aim/Background: Nifedipine (NIF) is act as Calcium channel blocker which belongs to chemical class dihydropyridine and used in the treatment of hypertension. An anal fissure (AF) is the most common anorectal conditions encountered in clinical practice. Patient anal fissures experience anal pain with defecation and minor bleeding. Emulgel formulations are considered a combination of emulsion and gels and emulgel has advantages of both. Emulgels have better penetration of actives than conventional topical formulations. Materials and Methods: Emulgel formulations are prepared with the lowest concentration of emulsifiers 1.5-4.0%. Carbomer homopolymer type C used as a polymeric emulsifier while formulating the formulation. The concentrations of Polymeric emulsifiers, high HLB surfactant and low HLB surfactants are varied to two level concentrations two optimize the formulations. Sorbitan monooleate and Polysorbate 20 used as surfactants. Results: Emulgel formulations are evaluated for homogeneity, consistency, grittiness, compatibility, pH, Viscosity, drug content, spreadability, extrudability and in-vitro drug release from the formulations. The optimized formulation has been charged for stability study at room temperature and accelerated storage condition. Stability results are similar to the initial results. In-vitro drug release profile of the initial time point versus 3M stability time point at accelerated and room temperature storage condition is similar. Conclusion: Carbomer homopolymer type C can be employeed as polymeric emulsifiers to stabilize unstable to stable emulsion.

Key words: Nifedipine, Polymeric emulsifiers (PE), Anal fissures, Emulgel, Evaluation of emulgel formulation.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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