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Published on:February 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(2):225-235
Original Article | doi:10.5530/ijper.53.2.30

Synthesis and Evaluation of Water Insoluble but Swellable Bioadhesive Polymer for Ocular Drug Delivery


Authors and affiliation (s):

Chaudhari Praveen*, Desai Ujwala

Department of Pharmaceutics, PES’ Modern college of Pharmacy, Sector no. 21, Yamunanagar, Nigdi, Pune 411044, Maharashtra, INDIA. 

Abstract:

Introduction: Our main purpose of present study was to find out the effect of different crosslinking agents along with its concentration during polymer synthesis and to find the most suitable polymer for ocular drug delivery with optimum bioadhesive strength and less irritation potential. It was expected that the synthesized polymer will remain adhered to the conjunctival mucin layer thus preventing loss of drug by precorneal factors. Materials and Methods: Acrylic acid procured from Loba chemicals was polymerized with Divinyl glycol from Merck specialities Private limited, Divinylbenzene and 2, 5-dimethyl-1, 5-hexadiene from Alfa Aesar to form water insoluble swellable polymer. Different parameters like density, polymer hydration, Differential Scanning Calorimetry, Infra-Red spectroscopy, X ray diffraction and mucoadhesive strength were determined. Polymer hydration was studied with respect to time, pH and ionic strength. HET-CAM test and Draize skin irritation test was performed to evaluate the degree of irritation caused by these polymers. Results and Discussion: It was found that as more hydrophobic groups were introduced in the polymer structure, hydration potential was reduced. The effect of concentration of crosslinking agent on bioadhesive strength was significant. With increase in density of crosslinking agent, the bioadhesive strength decreased. Polymers were found to be non-irritant to slight irritant in nature.

Key words: Bioadhesion, Ocular, Water Insoluble polymer, Acrylic acid, Hydration.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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