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Published on:July 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(3):382-399
Review Article | doi:10.5530/ijper.53.3.72

Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting

Authors and affiliation (s):

Priya Virendrakumar Shah, Sadhana Rajput*

Faculty of Pharmacy, Maharaja Sayajirao University of Baroda, Centre of Relevance and Excellence in New Drug Delivery System, Government of India, Vadodara, Gujarat, INDIA.


Background: In nanotechnology, the most promising inorganic materials for cancer targeting are Mesoporous silica nanoparticles (MSNs). This review gives a state of the art description of current status and applications of surface functionalized MSNs in the field of cancer theranostics. It also gives a detailed description of surface decorated MSNs researched upon so far in various types of cancer and the benefits associated with these. Applications: Ease of surface functionalization also offers additional functionalities like cell recognition, absorption of specific biomolecules, improving cell interaction and cellular uptake that significantly modifies the in vitro and in vivo behavior of the drug. Therefore, they have proved to be effective in gene delivery and multi drug resistance cancer treatment. Though, their biocompatibility still remains debatable. Biodegradation of MSNs is quite simple and it is safely excreted through kidneys via silanoic acid formation. Moreover, the USFDA has already approved the silica under the ‘GRAS’ category which has further made MSNs a thrust area for research in cancer theranostics. Summary: This review summarizes the journey of multifunctional MSNs beginning with its origin, mechanism of formation of mesoporous structure with surface functionalization to till date and recent advances in the arena of cancer targeting.

Key words: Mesoporous silica nanoparticles, Cancer targeting, Surface modification, Theranostics, Biomedical Application, Biodegradation.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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