Aim

The purpose of research was to refine the solubility and dissolution assessment of lurasidone hydrochloride, a poorly water-soluble drug with a pH dependent solubility, by preparing chitosan-based nanoparticles using the ionic gelation process with sodium Tripolyphosphate (TPP) as a conjoin factor.

Background

The poor water solubility and moderate oral bioavailability of antipsychotic medications provide a significant challenge in their oral distribution. The hydrophobic medication lurasidone hydrochloride revealed a limited therapeutic effect when compared to traditional drug delivery systems. To enhance the restorative effectiveness while reducing the adverse effects of traditional treatment, it is also necessary to investigate and develop new drug delivery systems.

Materials and Methods

modified ionotropic gelation process was used to make lurasidone hydrochloride loaded chitosan nanoparticles. Results: The prepared Formulation (F1) had a particle size of 222.2 nm and 85.32% drug entrapment efficiency. The maximal drug loading was determined and it was 82% in formulation F1, while the cumulative drug release was found to be 84.37%.

Conclusion

Due to the maximal solubility of lurasidone HCl at pH 7.4 phosphate buffer solution, it formed expanding cores and merged into nanoparticles. Based on the findings, it was determined that expanding chitosan nanoparticle is a viable method for enhancing the solubility and dissolution rate of Lurasidone HCl.