In the present work, a bibliographical survey of the toxicity of some plants of the southern Tunisia’s flora was conducted on several methanoic extracts from miscellaneous toxic plants of the southern Tunisian flora and chosen from among the most used plants in traditional medicine. In Tunisia, a host of extracts from about twenty plants have shown spasmolytic properties, while several extracts from some plants showed a high toxicity and 3 extracts from 2 plants proved curative properties. In this article, we present about ten poisonous plants, classified in alphabetical order of the vernacular name, for which severe poisoning, even fatal, have been reported. It mainly consists in plants with cardiac and/or neurological toxicity. Following a succinct description of the plant, we approach the clinical, therapeutic and analytical aspects.