1Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University-Anantapur, Ananthapuram, INDIA
2Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (Autonomous), KR. Palli Cross, (Affiliated to JNTU-Anantapur), Ananthapuram, INDIA
Corresponding author.
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ABSTRACT
Objectives
The study aimed to develop ocular films containing levofloxacin to treat conjunctivitis. These films were meticulously prepared using a combination of Gelatin, Aloe barbadensis leaves mucilage, and HPMC K4M, by the solvent casting technique, with the primary objective of enhancing the therapeutic efficacy of levofloxacin for this specific eye condition.
Materials and Methods
A comprehensive evaluation was carried out to ensure the quality and reliability of the films, encompassing parameters such as film thickness, weight variation, content uniformity, percentage moisture loss, and absorption capacity. In addition, in vitro drug release studies were conducted to simulate the eye’s conditions and understand the controlled release of the drug. The study also considered the influence of polymer concentrations, on drug release using Design Expert software’s Box Behnken Design.
Results
Notably, the research revealed that the ocular films followed zero-order kinetics, meaning they released the drug at a constant rate over time.
Conclusion
Furthermore, the films demonstrated stability under ambient conditions, making them a promising alternative for prolonged drug delivery and improved therapeutic outcomes in conjunctivitis treatment.