Home | Articles
Published on:March 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(1s):s112-s121
Original Article | doi:10.5530/ijper.55.1s.42

Formulation and Evaluation of Orodispersible Tablets of Apremilast by Inclusion Complexation using β-Cyclodextrin


Authors and affiliation (s):

Darshana Pravinchandra Panhale1,*, Rishikesh Shankar Bachhav2, Sheetal Bhaskar Gondkar3

1Department of Pharmaceutical Quality Assurance, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, INDIA.

2Department of Pharmacology, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, INDIA.

3Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, INDIA.

Abstract:

Introduction: The present study was carried out to formulate and evaluate orodispersible tablets of Apremilast with a purpose of providing better patient compliance to geriatric, pediatric, impaired, travelling and non-cooperative patients suffering from psoriasis. Such patients are in need of fast and easy swallowing drug delivery system. Materials and Methods: The Apremilast-β-cyclodextrin inclusion complex was prepared by physical blending method with a principle of increasing the solubility and permeability of drug. The inclusion efficiency of Apremilast: β-cyclodextrin ratios (1:1,1:2,1:3) were calculated and it was investigated that 1:2 ratio complex is highest. The orodispersible tablets of apremilast (F1 to F9) were prepared by simple and cost effective direct compression technique using different concentrations of super disintegrate croscarmellose sodium. Results: The results of pre-compression characteristics of powder blends and postcompression parameters of tablets were studied and showed satisfactory. Among all formulations studied, Formulation F6 showed less disintegration time and percent cumulative drug release 98.7% so it was declared as an optimized formulation. Conclusion: Therefore, It can be concluded that drug dissolution, absorption, therapeutic effect and bioavailability can be significantly greater than those as compared with conventional treatment of psoriasis in a cost-effective manner with better patient compliance.

Key words: Psoriasis, Orodispersible Tablet, Inclusion Complexation, Apremilast-β cyclodextrin, Croscarmellose sodium.

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs