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Published on:August 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(3):774-781
Original Article | doi:10.5530/ijper.55.3.150

Evaluation of in-vitro Immunomodulatory Activity and Thrombolytic Potential of Kabasura Kudineer (KSK): An Official Siddha Polyherbal Formulation

Authors and affiliation (s):

Sathiyarajeswaran Parameswaran1#, Shree Devi Munusamy Sampangi Ramulu1#,*, Vishnu Kirthi Arivarasan2#, Kanakavalli Kadarkarai3, Ramesh Kumar Dhanakoti4, Karthik Loganathan4

1Siddha Central Research Institute, Chennai, Tamil Nadu, INDIA.

2National Centre for Nanoscience’s and Nanotechnology, University of Mumbai, Vidyanagari, Santa Cruz (E), Kalina Campus, Mumbai, Maharashtra, INDIA.

3Central Council for Research in Siddha, Ministry of AYUSH, Chennai, Tamil Nadu, INDIA.

4Research and Development Centre, Salem Microbes Private Ltd., Salem, Tamil Nadu, INDIA. #Equal First Authorships


Aim: Coronavirus disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), attacking mainly on the immune system of a body. This has spread mortality and morbidity all over the world. During this dreadful situation there is an urgent need for the development and rapid dissemination of COVID-19 treatment. Siddha’s traditional medicine system can be used as preventive care to boost the immune system. Materials and Methods: The immense treasure of knowledge found in Siddha medicine can help mortality. Kabasura Kudineer (KSK) is one of the Siddha poly herbal formulation used as an immune-boosting agent against several diseases. Results: In the present study the KSK has been investigated for its effects of immunomodulatory and thrombolytic potential. The KSK at the concentrations of 12.5, 25, 50, and 100 μg/ml showed % immune-stimulations of 12.40 %, 20.81, 33.53, and 43.20 and for NBT showed 19.00, 25.50, 64.00, 71.00 % respectively. Moreover, similarly, the thrombolytic activity showed 50, and 100 μg/ml concentration showed 43.83 %, 71.83 % clot lysis, respectively, and the control value for the Streptokinase showed 83.78 %. Conclusion: Hence, it can be confirmed that KSK has immunomodulatory and thrombolytic properties in vitro models. Immunomodulatory and anti-thrombolytic are the steps to create a stable, safe, and efficient COVID-19 cure.

Key words: Kabasura Kudineer (KSK), Immunomodulatory, Thrombolytic, COVID-19, Siddha formulation.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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