Home | Articles
Published on:August 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(3):677-684
Original Article | doi:10.5530/ijper.55.3.139

Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate

Authors and affiliation (s):

Sagar Kumar Mohapatra1, Rudra Narayan Sahoo1,2, Subrata Mallick1, Rajaram Mohapatra1,*

1Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA.

2School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, INDIA.


Purpose: Oral drug delivery system has always been a preferred choice for the treatment of peptic ulcer and gastroesophageal reflux diseases. Being a proton pump inhibitor omeprazole restricts gastric acid secretion but the foremost downside is its degradation in acidic environments. The systemic absorption of gastro-unstable drugs can be improved by the enteric coating. Materials and Methods: This study was aimed at developing an effective enteric coating for omeprazole tablets using HPMC E5-LV and Hydroxypropyl Methylcellulose Acetate Succinate (HPMC-AS) polymers. The core tablets were subcoated with HPMC E5-LV which acted as a barrier between core tablet and enteric coated tablet. The enteric coating was applied using HPMC-AS. Results: Dissolution information unveiled that the enteric coat remained in place for 2 hr in acidic medium (0.1N HCl) and later dissolved when came in contact with basic media (acetate buffer pH 6.8), it dissolved within a jiffy. Conclusion: The release profile showed 91 to 98% drug release within 1hr in pH 6.8 Acetate buffer. Further instrumental analysis was performed to ascertain drug-polymer interaction.

Key words: Proton pump inhibitor, Enteric coating, HPMC, Omeprazole, Dissolution enhancement.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the Latest Release of Journal Citation Reports (source: Web of Science Data).


Impact Factor® as reported in the 2021 Journal Citation Reports® (Clarivate Analytics, 2022): 0.843

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs