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Published on:August 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(3):888-893
Original Article | doi:10.5530/ijper.55.3.163

Synthesis of Some Glycine Nicotinates and in-vivo Evaluation of Anti-Convulsant Activity for their Brain specific Slow Release Action


Authors and affiliation (s):

Kamta P. Namdeo1,*, Sushant K. Shrivastava2, Ramesh Chandra3

1SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur, Chhattisgarh, INDIA.

2Department of Pharmaceutics, IT BHU, Varanasi, Uttar Pradesh, INDIA.

3Department of Chemistry, University of Delhi, New Delhi, INDIA.

Abstract:

Aim: Purpose of the present work is to synthesize the pro-pro-drugs of Glycine and evaluate for their anticonvulsant activity in albino rats with brain specific sustained release action in various biological fluids. Materials and Methods: Prepared and synthesized propro- drugs of Glycine nicotinate by esterification with different alcohols and admiration with nicotinic acid. In present work pro-prodrug of Glycine nicotinate were synthesized by taking the Dihydropyridine as carrier molecules. The synthesized compounds have been characterized by IR, IH-NMR, C, H, N analysis and Mass spectral techniques and evaluated for their anticonvulsant activity in albino rats by chemoconvulsion method as well for oxidation in various biological fluids. All the synthesized compounds were found to be active and stable in biological fluids. Oxidized form of the conjugate inside the brain act as pro-pro-drug, which on hydrolysis yields parent drug in sustained release manner. The significance of the work is to treat neurological disorder implicated by Glycine. Results: Pro-pro-drug of Glycine nicotinate were synthesized effectively and showed anticonvulsant activity in slow release manners. Conclusion: This work has given a new synthetic strategy and result of anticonvulsant screening was found encouraging.

Key words: Dihydropyridine, Pro-pro-drug, Nicotinylglycine, Glycine nicotinate, Antiepileptic.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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