Home | Articles
Published on:November 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(3s):S672-S680
Original Article | doi:10.5530/ijper.55.3s.174

Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization

Authors and affiliation (s):

Vedanshu Malviya1,*, Prashant Burange2, Yashdeepsingh Thakur2, Mukund Tawar2

1Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Kathora, Amravati, Maharashtra, INDIA.

2Department of Pharmaceutical Chemistry, P.R. Pote Patil College of Pharmacy, Kathora Road, Amravati, Maharashtra, INDIA.


Objectives: The current objective of the present study was to enhance the solubility and dissolution rate of the antiviral drug atazanavir sulphate by employing nanocrystallization technique. Materials and Methods: The method employed for increment of solubility was nanocrystallization which is based on the reduction of particle size of the drug thereby increasing its solubility and also its dissolution property. Various polymers in different ratios were used like HPMC K15M, PVP K30 and PEG 6000. Results: Drug and polymers were firstly tested for their interaction between each other’s and it was found that the drug and polymers are compatible with each other. From the solubility study it was seen that the solubility of the optimized batch was increased to 40.068mg/ml in distilled water and 160.182mg/ml in phosphate buffer while the pure drug shows the solubility of 4.174mg/ml in distilled water and 20.547mg/ml in phosphate buffer. The percent drug release of the optimized formulation was seen of 87.91% in 2 hrs which was maximum from all the other batches. The stability study revealed that the prepared nanocrystal does not show any insignificant changes and therefore it can be concluded as stable. Conclusion: The prepared nanocrystals are the proof that this method of nanocrystallization may prove to be an efficient method in increasing the solubility and dissolution rate of the drug which are having low solubility and low bioavailability.

Key words: Atazanavir Sulphate, Nanocrystallization, Solubility Enhancement, Dissolution Enhancement, Antiviral.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs