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Published on:March 2022
Indian Journal of Pharmaceutical Education and Research, 2022; 56(2):573-579
Original Article | doi:10.5530/ijper.56.2.80

Synthesis of Transition Metal Complexes of Isoniazid Derivatives and Urease Inhibition Activity Detection


Authors and affiliation (s):

Yi-Heng Zhang, Ze-Yu Fang, Juan Sun*, Yuan-Feng Wu*

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, CHINA.

Abstract:

It have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd2(L)2·(H2O)] (1), [Pb(L)·, [Pbe2) were synthesized based on chelating hydrazone ligand N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested by single crystal X-ray diffraction and determined by structure and tested for urease resistance in vitro. The complex 2 exhibited better the activities of inhibiting than the positive control acetohydroxamic acid with an IC50 =2.5 μM, while the complex 1 showed weak activity, and complex 2 acted as an effective urease inhibitor.

Key words: Cadmium(II) complexes, Plumbum(II) complexes, Crystal structure, Schiff base, Urease inhibitor.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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