Synthesis of Transition Metal Complexes of Isoniazid Derivatives and Urease Inhibition Activity Detection

Abstract:

It have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd₂(L)₂·(H₂O)] (1), [Pb(L)·, [Pbe₂) were synthesized based on chelating hydrazone ligand N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested by single crystal X-ray diffraction and determined by structure and tested for urease resistance in vitro. The complex 2 exhibited better the activities of inhibiting than the positive control acetohydroxamic acid with an IC₅₀ =2.5 μM, while the complex 1 showed weak activity, and complex 2 acted as an effective urease inhibitor.

Key words: Cadmium(II) complexes, Plumbum(II) complexes, Crystal structure, Schiff base, Urease inhibitor.