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Published on:March 2022
Indian Journal of Pharmaceutical Education and Research, 2022; 56(2):573-579
Original Article | doi:10.5530/ijper.56.2.80

Synthesis of Transition Metal Complexes of Isoniazid Derivatives and Urease Inhibition Activity Detection

Authors and affiliation (s):

Yi-Heng Zhang, Ze-Yu Fang, Juan Sun*, Yuan-Feng Wu*

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, CHINA.


It have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd2(L)2·(H2O)] (1), [Pb(L)·, [Pbe2) were synthesized based on chelating hydrazone ligand N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested by single crystal X-ray diffraction and determined by structure and tested for urease resistance in vitro. The complex 2 exhibited better the activities of inhibiting than the positive control acetohydroxamic acid with an IC50 =2.5 μM, while the complex 1 showed weak activity, and complex 2 acted as an effective urease inhibitor.

Key words: Cadmium(II) complexes, Plumbum(II) complexes, Crystal structure, Schiff base, Urease inhibitor.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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