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Published on:June 2022
Indian Journal of Pharmaceutical Education and Research, 2022; 56(3):780-788
Original Article | doi:10.5530/ijper.56.3.128

Hydroalcoholic Carthamus tinctorius L. Extract Attenuates TNBS-induced Ulcerative Colitis in Mice Via Downregulation of Inflammation and Oxidative Stress


Authors and affiliation (s):

Li Zhang1,*, Zhongbao Niu2

1Department of Anorectal, The People’s Hospital of Huaiyin, Jinan, Shandong, CHINA.

2Department of Traditional Chinese Medicine, Shandong Provincial Hospital (Affiliated to Shandong First Medical University), Jinan, Shandong, CHINA.

Abstract:

Background: Ulcerative colitis (UC) is distinct by severe inflammation of intestinal epithelial tissue and more than 2 million people worldwide are affected with ulcerative colitis. This disease is primarily driven by oxidative stress and inflammation. Objectives: To identify a safer remedy with less/no adverse effect, we investigated the beneficial ability of Carthamus tinctorius L. extracts to alleviate multi-factorial conditions like oxidative stress, lipid peroxidation, and inflammation in Trinitro benzenesulfonic acid induced experimental ulcerative colitis in mice. Materials and Methods: Ulcerative colitis in Balb/c mice were induced by intrarectal administration of TNBS. Hydroalcoholic Carthamus tinctorius L. extracts were supplemented orally and all mice were observed and scored for clinical manifestations. After sacrificing mice, inflammatory markers, colonic oxidative stress levels, and antioxidant enzymes were measured. Histological features of the colon were also analyzed. Results: Supplementing the TNBS-induced group with the plant extracts suppressed oxidative stress, enhanced cytoprotective antioxidants, and reduced inflammation. The histological evaluation also showed restoration of damaged tissues. Conclusion: Our findings indicate the curative ability of the hydroalcoholic Carthamus tinctorius L. extracts and can be a good therapeutic candidate to treat Ulcerative colitis.

Keywords: Ulcerative colitis, TNBS, Carthamus tinctorius L., Oxidative stress, Inflammation.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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