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Published on:September 2023
Indian Journal of Pharmaceutical Education and Research, 2023; 57(4):1226-1231.
Original Article | doi:10.5530/ijper.57.4.146

Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis


Authors and affiliation (s):

Sania Bashir1 , Fatima Qamar1,*, Safila Naveed1 , Syeda Zainab2 , Halima Sadia1 , Aisha Sana1 , Wajeeha Muzafar3

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.

2Department of Pharmaceutics, Jinnah University for Women, Karachi, PAKISTAN.

3Department of Chemistry, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PAKISTAN.

Abstract:

Aim: Simple RP-HPLC method was developed and validated for the simultaneous estimation of Glimepiride, Glibenclamide and Moxifloxacin in pharmaceutical preparation. Materials and Methods: Mediterranean C18 column with dimensions of 150mm×4.6mm was used with HPLC Shimadzu_ LC-20 AT model, Version 1:62 is used for processing of chromatograms at room temperature (25± 2°C). 1 mL per minute was the flow rate and detector were set at 254nm with mobile Phase consisting of 85:10:5 v/v methanol: water: acetonitrile. Results: The developed method proved to be accurate, simple, effective precise and reproducible. One way ANOVA was also applied for further confirmation of the results. Conclusion: The method is applicable for the routine analysis of drugs in API and in formulation and for studying in vitro interaction studies.

Keywords: Moxifloxacin, Glimepiride, Glibenclamide, in vitro interaction studies

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