1Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Ananthapuramu, INDIA
2Department of Pharmaceutics, Creative Educational Society’s College of Pharmacy-(CESCOP) Affiliated to Jawaharlal Nehru Technological University, Ananthapuramu, INDIA
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ABSTRACT
Objectives
The project intends to create and evaluate oral fast-dissolving Ondansetron (ODN) films and explore how different plasticizers and polymers affect ondansetron release at varied doses.
Materials and Methods
The solvent casting method was used to make the films. Complex formation and compatibility were evaluated using spectral and calorimetric methods to confirm. Utilising the core composite design, which included 13 different Ondansetron Fast-Dissolving Oral Films (OFDOFs) formulas, the produced Ondansetron Fast-Dissolving Oral Films (OFDOFs) were optimised. Using the Design Expert-v.11 software, the impacts of three variables, including HPMC K4M (X1), Carbopol 934 P (X2), and propylene glycol levels (X3), on two responses, Folding Endurance (FE) and Swelling Index (SI), were examined. Numerical optimisation increased the FE (Y1) and maximised the SI (Y2).
Results
The statistical analysis findings showed that X1 greatly enhances Y1 and Y2. While X2 and X3 significantly prejudiced the responses optimistically. It was found that the best films were created at the midpoint concentration of both X1 and X2. Moreover, as X3 levels increased, the elasticity and FE also improved, in addition to the film’s quality.
Conclusion
The study concludes that the prepared buccal films of ODN exhibited great mechanical and physical qualities in addition to their other physicochemical assets. This dosage form is expected to offer a bioavailability benefit over conventional dosage forms due to its rapid onset of action and anticipated partial avoidance of pre-systemic metabolism.