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ABSTRACT
Aim of the Study
To assess the antidiarrheal properties of Evodiamine in the prevention and treatment of Chemotherapy-Induced Diarrhea (CID) in experimental rats.
Materials and Methods
The Swiss albino female rats (8-12 weeks) rats were treated with Evodiamine for 13 days and 5-FU was administered on day 4 to day 10 (7 consecutive days) for the induction of diarrhea. After 13 days of experiments, all rats were euthanized and thymus and spleen weights were measured. Bodyweight and diarrhea rate and score were recorded every day.
Results
Our study resulted that Evodiamine significantly prevented and reduced the rate and intensity of diarrhea, body weight and thymus/spleen indexes in dose-dependently. The highest effects were observed with Evodiamine 50 and 100 mg/kg which exhibited a similar effect with that of loperamide (3 mg/kg).
Conclusion
Our findings demonstrated the antidiarrheal activity of Evodiamine for the prevention of 5-FU induced diarrhea. This is the first-ever study reporting on the antidiarrheal potential of Evodiamine against chemotherapy-induced diarrhea.